Table 2 Association of AR, EZH2, Ki67, PTEN and SPINK with AURKA in CRPC specimens. AURKA positivity was associated with staining of AR, Ki67, EZH2 and PTEN expression levels in AR positive CRPC samples (NEPCs were excluded from the analysis)
From: The expression of AURKA is androgen regulated in castration-resistant prostate cancer
Variable | AURKA expression | P | |
|---|---|---|---|
Negative | Positive | ||
Met-CRPCs: | |||
  AR expression, n (%)a | |||
  weak | 31 (44) | 4 (20) |  |
  moderate | 30 (43) | 7 (35) |  |
  strong | 9 (13) | 9 (45) | 0.005 |
 ERG expression, n (%)b | |||
  negative | 37 (60) | 4 (20) |  |
  positive | 25 (40) | 16 (80) | 0.004 |
PTEN expression, n (%)b | |||
  negative | 42 (68) | 11 (55) |  |
  positive | 20 (32) | 9 (45) | 0.420 |
p53 expression, n (%)b | |||
  negative | 40 (62) | 16 (84) |  |
  positive | 25 (38) | 3 (16) | 0.096 |
SPINK expression, n (%)b | |||
  negative | 54 (87) | 16 (80) |  |
  positive | 8 (13) | 4 (20) | 0.474 |
  Ki-67 (mean +/− SD)d | 9.3 (9.5) | 14.5 (9.3) | 0.025 |
  EZH2 (mean +/− SD)d | 27.9 (22.4) | 39.6 (20.4) | 0.035 |
Local CRPCs | |||
 AR expression, n (%)a | |||
  weak | 1 (4) | 1 (6) |  |
  moderate | 9 (39) | 6 (38) |  |
  strong | 13 (57) | 9 (56) | 0.073 |
ERG expression, n (%)b | |||
  negative | 10 (38) | 9 (56) |  |
  positive | 16 (62) | 7 (44) | 0.344 |
PTEN expression, n (%)b | |||
  negative | 6 (60) | 7 (58) |  |
  positive | 4 (40) | 5 (42) | 1.000 |
SPINK expression, n (%)b | |||
  negative | 12 (86) | 8 (67) |  |
  positive | 2 (14) | 4 (33) | 0.365 |
  Ki-67 (mean +/− SD)d | 14.4 (9.1) | 18.1 (11.1) | 0.318 |
  EZH2 (mean +/− SD)d | 39.2 (29.6) | 58.9 (21.9) | 0.032 |
