Table 1 List of canonical pathways identified by IPA that are common between the two diseases and described in this study.

From: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

Ingenuity Canonical Pathways

−log(p-value)

Rcd1

Xlpra2

Complement System

5.03 ↑

5.82 ↑

Inflammasome pathway

1.26 ↑

1.75 ↑

JAK/Stat Signaling

2.18 ↑

1.68 ↑

NF-κB Signaling

5.29 ↑

5.36 ↑

Prolactin Signaling

2.53 ↑

2.91 ↑

STAT3 Pathway

4.72 ↑

2.54 ↑

TNFR1 Signaling

1.56 ↑

0.795 ↑

TNFR2 Signaling

1.46 ↑

1.72 ↑

Toll-like Receptor Signaling

4.61 ↑

4.57 ↑

  1. Pathways are listed alphabetically; all pathways in this list were predicted to be activated (↑) based on z-score obtained from IPA. The p-value threshold was set at 0.05 (−log(p-value) equivalent 1.3). A complete list of canonical pathways that were selected for IPA canonical pathway analysis for the two mutants is listed in Supplementary Table 3. A more comprehensive analysis with no exclusions is provided in Supplementary Table 4.
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