Figure 2

Overall structures of PPARγ LBD in complex with lobeglitazone and with rosiglitazone. Lobeglitazone-bound and rosiglitazone-bound PPARγ LBD structures are superimposed and colored in salmon and yellow orange, respectively, all of which include the SRC-1 coactivator peptide colored same with bound PPARγ LBD structures. Lobeglitazone and rosiglitazone are represented as a stick model in green and pale cyan, respectively. Ser245 (PPARγ1 numbering; Ser273 in PPARγ2 numbering) is the Cdk5-mediated phosphorylation site, shown by red sticks. Regions with RMSD 2.0 Å and bigger are indicated with blue dashed circles. Overall structures are shown in stereo view.