Figure 3

Structural comparison of lobeglitazone-bound, rosiglitazone-bound, and apo PPARγ LBD structures. RMSD values of lobeglitazone-bound vs. rosiglitazone-bound, lobeglitazone-bound vs. apo PPARγ (PDB ID: 1PRG), and rosiglitazone-bound vs. apo PPARγ were calculated and represented in red, blue, and green lines, respectively. Secondary structure elements are indicated on the residue numbers. Regions with RMSD 2.0 Å and bigger are marked with blue down arrows. Residues 262–272 are disordered in the PPARγ LBD structures and were excluded from calculations.