Figure 6
From: Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
Interactions of the p-methoxyphenol group of lobeglitazone with PPARγ LBD. (a) The lobeglitazone-bound PPARγ LBD structure is shown in a ribbon diagram (salmon) and lobeglitazone is represented by a green stick. The residues forming the hydrophobic pocket are shown in gray sticks. The p-methoxyphenol group of lobeglitazone occupies the hydrophobic pocket. The hydrogen bond between the p-methoxyphenol group of lobeglitazone and Nη atom of Arg280 is depicted by dashed line and labeled with donor–acceptor distance in Å. (b) The rosiglitazone-bound PPARγ LBD structure is shown in a ribbon diagram (yellow orange) and rosiglitazone is represented by a pale cyan stick. The hydrophobic pocket is not occupied. Interaction between rosiglitazone and Arg280 is not observed.
