Figure 7
From: Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
Superposition of lobeglitazone with other PPARγ ligands from known complex structures. 131 PPARγ LBD structures with bound ligand in PDB were superimposed onto the lobeglitazone-bound structure (ribbon in salmon) and lobeglitazone is shown by a green stick while the other ligands are shown in blue lines. Most ligands occupy the canonical LBP with Y-shaped pocket. The Cdk5-mediated phosphorylation site, Ser245, is represented by red sticks. The residues forming the hydrophobic pocket are shown in gray sticks.
