Figure 6
From: Influence of solubilization and AD-mutations on stability and structure of human presenilins
Temperature induced aggregation of presenilin2 visualized by SDS-PAGE. (a) The same concentration of PS2 in FC14 was heated at identical heating rate as in the CD melting experiment. At the respective temperatures (°C, top of lane) aliquots of 3.5 µg of PS2 were applied to a 12% SDS-PAGE; (b) Densitometric analysis of aggregation of PS2 on SDS-PAGE. Solid lines represent the fitting of the data into equation (2) (see Methods).
