Figure 2 | Scientific Reports

Figure 2

From: Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation

Figure 2

Expression of E-cadherin/CDH1 and P16/CDKN2A in PDC subjects. Diffuse membranous expression of E-cadherin/CDH1 was apparent in tumor cells (arrow) of non-DM (A) and short-DM (B) whereas the expression was equivocal (arrow) in long-DM showing diffuse invasive growth (C). E-cadherin/CDH1 was uniformly expressed in normal ductal structure adjacent to tumor tissues in non-DM (D), short-DM (E) and long-DM (F). The expression of P16/CDKN2A was sparse in the nuclei of tumor cells (arrow) in non-DM (G), short-DM (H) and long-DM (I) and there were no differences among groups. The expression in normal ducts (arrow) adjacent to PDC was comparable in non-DM (G), short-DM (H) and long-DM (I). Bar represents 50 μm in each.

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