Figure 3

Scattered plots for E-cadherin/CDH1 expression in the investigated groups. Decreased membrane expression of E-cadherin/CDH1 (Score 2≧) was evident in PDC with long-DM (*p < 0.01 vs non-DM and short-DM) (A). The v- and ly-factor scores as markers of venular and lymph vessel invasion were significantly increased in a group with low E-cadherin expression (Score 2≧) compared to a group with high expression (Score 3) (*p < 0.05) (B). Similarly, group with positive CDH1 promoter methylation showed significant increases in v- and ly-factors compared to group with negative CDH1 promoter methylation (*p < 0.05) (C).