Figure 4

Stratification of DCM patients using transcriptomic and genetic profiles. (a) Stratification using gene expression (subgroup A has 32 patients and subgroup B has 45 patients); (b) Stratification using eSNPs (subgroup A has 18 patients and subgroup B has 59 patients). 77 DCM patients are stratified based on gene expression or eSNPs of Hridaya-genes. Hierarchical clustering is done, and the patients are divided into two subgroups. The significant phenotypes of these two subgroups are shown. The binary phenotypes are shown as bar plots indicating the percentage (%) of the individuals in each subgroup having a particular phenotype. The continuous valued phenotypes (in centimeter, cm) are shown as box plots. The p-value of the phenotypic differences between the two subgroups using either Wilcoxon rank-sum test (continuous valued phenotype) or Fischer test (binary valued phenotype) are shown in each figure, and the title of each figure shows the phenotype described. Significant phenotypic differences between the two subgroups are observed for LVESD, LVEDD, and if patients have taken drugs like Milronine, Hydralazine, Nitrate, Beta blockers, Angiotensin II Antagonists.