Figure 6
From: Characterization of Dopaminergic System in the Striatum of Young Adult Park2−/− Knockout Rats
The effect of parkin protein loss on the levels of postsynaptic dopamine D2 receptor and dopamine transporter in the rat striatum. Tissue lysates were prepared form striata of the 2 month-old parkin knockout (PKO) and wild type (WT) Long Evans male rats. (A) The levels of postsynaptic D2 receptor (D2L) (~55 kDa) were significantly decreased (−27%, p < 0.01, Student’s t-test, n = 7–9) in the striatum of PKO rats compared to the striatum of WT controls. (B) The immunoreactivity of glycosylated dopamine transporter (DAT) (detected at ~70 kDa) did not significantly differ between the PKO and WT phenotypes in the majority of the PKO rats (n = 15–17). The data are expressed as mean ± SEM, **p < 0.01.
