Figure 9
From: Characterization of Dopaminergic System in the Striatum of Young Adult Park2−/− Knockout Rats
The effect of parkin protein loss on motor behaviors. The parkin knockout (PKO) and wild type (WT) Long Evans male rats were assessed for locomotor activity, stereotypic movements at the response to 2 mg/kg methamphetamine at the age of 2 months. (A) Compared to the WT controls, the PKO rats showed a significantly decreased stereotypic movements (−18%, p < 0.05, Student’s t-test, n = 6). (B) There was no difference between PKO and WT rats in distance traveled over 30 min. (C) The locomotor response of PKO to 2 mg/kg dose of methamphetamine (METH) was significantly lower than the response of WT controls (−39%, Student’s t-test, p < 0.01, n = 6). The data are expressed as mean ± SEM. *p < 0.05, **p < 0.01.
