Figure 7 | Scientific Reports

Figure 7

From: Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model

Figure 7

Schematic diagram of therapeutic effect of hUCB-MSCs on Aβ peptide-induced synaptic dysfunction. Oligomeric low-concentration of Aβ peptide induced loss in synaptic function and reduced expression of TSP-1 receptors in hippocampal neurons. Interestingly, hUCB-MSC-derived TSP-1 promoted elevation of synaptic function via TSP-1 receptors as well as recovery of TSP-1 receptors such as NLGN1 and α2δ-1. Consequently, TSP-1-secreting hUCB-MSCs may reveal therapeutic effects on Aβ peptide-induced synaptic dysfunction.

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