Table 3 Performance of individual bacterial species and combinations of bacterial species for gastric cancer diagnosis.

From: Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan

 

Cc

Fc

Fn

Lg

Lr

Cc + Fn

Cc + Fc + Fn

Cc + Fc + Fn + Lg + Lr

AUROC

73.3%

68.2%

68.8%

84.7%

90.3%

87.5%

89.2%

93.8%

SE

0.108

0.111

0.112

0.084

0.065

0.066

0.060

0.044

p-value

0.043

0.114

0.103

0.003

<0.001

0.001

0.001

<0.001

95% CI

0.52–0.95

0.47–0.90

0.47–0.91

0.68–1.011

0.78–1.03

0.75–1.00

0.77–1.01

0.85–1.02

Cut-off

9.21 × 10−4

2.00 × 10−4

1.10 × 10−3

5.07 × 10−6

2.53 × 10−5

1.12 × 10−3

1.22 × 10−3

3.86 × 10−2

Sensitivity

45.5%

54.5%

72.7%

81.8%

81.8%

100%

100%

72.7%

Specificity

0.00%

87.5%

68.8%

81.3%

87.5%

68.8%

68.8%

100%

PPV

23.8%

75.0%

61.5%

75.0%

81.8%

68.8%

68.8%

100%

NPV

0.00%

73.7%

78.6%

86.7%

87.5%

100%

100%

84.2%

  1. Abbreviations: AUROC, area under the receiver operating characteristics curve; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; SE, standard error. Bacterial species: Cc, Clostridium colicanis; Fc, Fusobacterium canifelinum; Fn, Fusobacterium nucleatum; Lg, Lactobacillus gasseri; Lr, Lactobacillus reuteri.