Figure 1
From: Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms
Comparison of the amount of MNC-NAIP between healthy controls and ALS patients. (A) Dot blot analysis of NAIP using mononuclear cells (MNC) from healthy controls and ALS patients was performed with anti-NAIP antiserum. The density of each NAIP dot signal was quantified per μg of whole protein extract from the MNC. The black, gray, horizontal lines and slash line bars indicate the amount of NAIP at baseline, 4 months, 8 months, and 12 months, respectively. Data are expressed as mean ± SD (n = 4 technical replicates). Case A7–A12 were followed up to 12 months. Case A2, A4, and A14 died within testing period. Case A1, A5, and A6 could not visit clinic at fixed testing intervals. Case A3, A13, A15–A18 discontinued after participating in edaravone clinical study. (B) The amount of MNC-NAIP at baseline between ALS patients (n = 18) and healthy controls (n = 12) is shown as Mean Diamonds. P = 0.0019 by t test.
