Figure 2
Combination of SEP and αPD-L1 results in additive upregulation of cytotoxicity activity of splenocytes in B16-F10-bearing mice. The spleens were collected from treated mice in each group (n = 3) at the end of the experiment (day 16), and the single-cell suspensions were prepared. The cytotoxic activity of splenocytes at E/T ratios of 10:1, 20:1 and 40:1 were increased in three treatment groups (each treatment P < 0.05 at every ratio, n = 3). Combination of SEP and αPD-L1 had significantly additive upregulation of cytotoxicity effects of splenocytes compared with SEP (P < 0.05 at every ratio, n = 3) or αPD-L1 (P < 0.05 at every ratio, n = 3). The results were presented as mean ± SEM. * P < 0.05 compared with control group. # P < 0.05, compared with SEP group. & P < 0.05, compared with αPD-L1 group.
