Figure 5
Combination of SEP and αPD-L1 on the effects of IFN-γ and IL-2 levels from spleen (A and C) and tumor (B and D) in B16-F10-bearing mice. The mouse spleens and tumors were harvested at the end of the experiment (day 16). The increase in IFN-γ and IL-2 levels in spleen or tumor was observed in three treatment groups compared with the control group (each treatment P < 0.05 for each cytokine, respectively, n = 6). And, combination of SEP and αPD-L1 had significantly additive increase of IFN-γ and IL-2 levels compared with SEP (each cytokine P < 0.05 in spleen or tumor, respectively, n = 6) or αPD-L1 (each cytokine P < 0.05 in spleen or tumor, respectively, n = 6). The results were presented as mean ± SEM. * P < 0.05, compared with control group. # P < 0.05, compared with SEP group. & P < 0.05, compared with αPD-L1 group.
