Table 3 Association of subcellular location of AID and A3s with region of adenoids and palatine tonsils. The subcellular location of immunoreactive cells was separately evaluated for nucleus and cytoplasm.

From: Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils

  

Adenoid (n = 14)

Palatine tonsil (n = 15)

  

Epithelium (mean ± SD)

P

Epithelium (mean ± SD)

P

Folliclular GC (mean ± SD)

P

AID

N+C score

3.37 ± 0.89

 

3.26 ± 0.33

 

2.54 ± 1.19

 

N scoreC score

1.44 ± 0.75

0.029*

1.50 ± 0.83

0.511

0.85 ± 0.62

0.001**

1.93 ± 0.25

1.76 ± 0.56

1.69 ± 0.72

A3A

N+C score

2.17 ± 0.35

 

1.97 ± 0.93

 

1.21 ± 1.51

 

N scoreC score

1.88 ± 0.20

<0.001***

1.59 ± 0.57

<0.001***

0.78 ± 0.76

0.094

0.28 ± 0.35

0.38 ± 0.56

0.42 ± 0.80

A3B

N+C score

2.41 ± 1.27

 

2.58 ± 1.23

 

1.79 ± 1.24

 

N scoreC score

0.75 ± 0.81

0.038*

0.88 ± 0.76

0.040*

1.36 ± 0.55

0.008*

1.67 ± 0.62

1.70 ± 0.60

0.51 ± 0.72

A3C

N+C score

2.86 ± 1.06

 

2.00 ± 0.92

 

1.95 ± 1.14

 

N scoreC score

1.04 ± 0.77

0.006**

0.35 ± 0.60

<0.001***

0.45 ± 0.44

0.002**

1.82 ± 0.41

1.64 ± 0.51

1.50 ± 0.80

A3D

N+C score

0.62 ± 0.81

 

0.35 ± 0.56

 

0.92 ± 0.74

 

N scoreC score

0

0.061

0

0.056

0.02 ± 0.08

<0.001***

0.62 ± 0.81

0.35 ± 0.56

0.90 ± 0.72

A3F

N+C score

2.05 ± 1.08

 

2.42 ± 0.79

 

1.83 ± 1.07

 

N scoreC score

0.33 ± 0.61

0.011*

0.79 ± 0.56

0.003**

0.29 ± 0.70

0.007*

1.71 ± 0.76

1.75 ± 0.39

1.54 ± 0.59

A3G

N+C score

2.37 ± 1.11

 

1.73 ± 0.84

 

2.33 ± 0.59

 

N scoreC score

0.62 ± 0.85

0.001**

0.23 ± 0.40

<0.001***

0.52 ± 0.38

<0.001***

1.75 ± 0.44

1.50 ± 0.61

1.81 ± 0.31

A3H

N+C score

3.11 ± 0.94

 

2.78 ± 0.97

 

3.31 ± 0.80

 

N scoreC score

1.28 ± 0.64

0.010*

1.00 ± 0.67

0.002**

1.30 ± 0.80

0.024**

1.82 ± 0.37

1.78 ± 0.36

2.00

  1. Expression score 0, <10% immunoreactive cells; expression score 1, 10%–50% immunoreactive cells; expression score 2, >50% immunoreactive cells.
  2. N + C score, the total expression score; N score, the nucleus expression score; C score, the cytoplasm expression score.
  3. n, patient number; SD, standard deviation.
  4. P, P-value for correlation of N score and C score by the Mann–Whitney U test.
  5. *P < 0.05; **P < 0.01; ***P < 0.001.
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