Figure 1 | Scientific Reports

Figure 1

From: Tanshinone IIA sulfonate protects against cigarette smoke-induced COPD and down-regulation of CFTR in mice

Figure 1

STS attenuates CS-induced body weight loss, increases of liver and spleen indices in mice. Mice with LPS intranasally inhaled (7.5 μg/mouse in 50 μl saline) at the 1st and 14th day were exposed to CS from day 0 to 60 except for the days giving LPS. Aerosol STS (5 mg/kg) was given to mice 30 min before CS exposure. (A) The scheme of CS plus LPS expousures as well as STS treatment. (B) During the experiments, mouse weight was monitored. At the end of the experiment, (C) the weight ratios of liver to whole body, (D) spleen to whole body and (E) kidney to whole body were measured. *P < 0.05 and **P < 0.01 (n = 8–11 mice per group). LPS, lipopolysaccharide; STS, Sodium tanshinone IIA sulfonate; CS, cigarette smoke.

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