Figure 5 | Scientific Reports

Figure 5

From: Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters

Figure 5

Electron micrographs of the NMJs and muscle fibers of the left diaphragms. (A–D) Representative electron micrographs of the left diaphragm NMJs of Fgf18+/+ and Fgf18−/− mice at E18.5. A red arrowhead indicates a postsynaptic fold. SV, synaptic vesicles. Boxed areas in (A) and (B) are enlarged in (C) and (D), respectively. Blinded morphometric measurements are shown in Table 1. Bar = 2 μm in (A) and (B). Bar = 500 nm in (C) and (D). (E,F) Representative electron micrographs of the diaphragm muscle fibers of Fgf18+/+ and Fgf18−/− mice at E18.5. Thickness of muscle fibers at the Z disk in the diaphragms of Fgf18+/+ and Fgf18−/− mice are 0.82 ± 0.35 and 0.85 ± 0.43 μm (mean and SD, n = 5 mice), respectively, with no statistical significance by Student’s t-test (not shown). Bar = 500 nm.

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