Table 1 Comparison of binding and functional Ab responses induced in VAX003 and VAX004 vaccine recipients at peak vs final time pointsa.

From: Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials

 

VAX003

VAX004

Binding Absb

gp120

NS

NS

V1V2-gp70 (B.Case A2)

NS

NS

V1V2-tags (C.1086)

***

NS

CycV2 (AE.92TH023 or B.MN)

****

**

V3 full length (B.MN)

****

NS

V3 crown

**

**

V3 cradle

***

*

V3 ladle

NS

NS

 

VAX003 & VAX004

Functional Abs c

Neutralization (B.SF162)

**

V3 Ab Neutralization

**

V3 ADCP

ND

gp120 ADCC

**

  1. aResponses at peak and final time points were compared by t test (paired, 2-tailed).
  2. bELISA data from Figs 1, 2 and 3.
  3. cData from Figs 5, 6, 7 and 8.
  4. NS: not significant (P ≥ 0.05), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
  5. ND: statistical analysis was not done.
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