Figure 6

Flow diagram of the histogram analysis. The total VOI was determined with the semiautomatic segmentation method. Based on geometric information stored in the respective data sets of a dedicated imaging processing software, structural MR images such as CE T1WI (1^st step, left) and FLAIR (1^st step, right) were co-registered with the DSC PWI driven maps, such as the nCBV map with leakage correction (2^nd step, left), nCBV map without leakage correction (2^nd step, middle), and leakage map (2^nd step, right). After acquiring co-registered images on a voxel-by-voxel basis, the total VOIs were drawn (3^rd step) on enhancing lesions of CE T1WI and hyperintense lesions of FLAIR. Finally, the overall values for each tumor were obtained by the summation of the histogram parameter values from every plane.