Table 1 Physiological steady state parameters, WT vs. Cav1−/− mice.
WT (n = 6) | Cav-1−/− (n = 6) | |
|---|---|---|
Plasma parameters (mean ± SD) | ||
Na+, mmol/L | 152.1 ± 1.5 | 143.7 ± 12.0 |
K+, mmol/L | 5.9 ± 0.3 | 6.2 ± 0.8 |
Cl−, mmol/L | ||
Ca2+, mmol/L | 1.88 ± 0.05 | 1.90 ± 0.03 |
Creatinine, mg/dl | 0.11 ± 0.01 | 0.10 ± 0.01 |
Urea, mg/dl | 54.5 ± 4.4 | 55.4 ± 7.4 |
Urinary analysis (mean ± SD) | ||
Body weight, g | 28.3 ± 0.8 | 29.8 ± 0.8 |
Urinary volume, g/g body weight | 0.023 ± 0.005 | 0.052 ± 0.010* |
Na+ excretion, mmol/kg*24 h | 2.6 ± 1.5 | 6.3 ± 1.5* |
K+ excretion, mmol/kg*24 h | 5.2 ± 1.6 | 8.2 ± 1.9 |
Cl− excretion, mmol/kg*24 h | 3.6 ± 0.9 | 7.7 ± 2.1 |
Ca2+ excretion, mmol/kg*24 h | 0.07 ± 0.01 | 0.16 ± 0.06 |
Creatinine, mg/dl | 41.2 ± 4.2 | 24.7 ± 5.1 |
Creatinine, mg/g body weight | 0.009 ± 0.002 | 0.011 ± 0.001 |
Na+/creatinine ratio | 33.7 ± 4.2 | 65.4 ± 12.1* |
K+/creatinine ratio | 66.4 ± 10.7 | 85.1 ± 17.2 |
Cl−/creatinine ratio | 45.9 ± 4.6 | 80.6 ± 19.0 |
Ca2+/creatinine ratio | 0.95 ± 0.09 | 1.64 ± 0.62 |
Renal function (mean ± SD) | ||
Fractional Na+ excretion, % | 0.22 ± 0.03 | 0.40 ± 0.06* |
Fractional K+ excretion, % | 10.83 ± 1.68 | 12.68 ± 1.75 |
Fractional Cl− excretion, % | 0.42 ± 0.04 | 0.87 ± 0.13* |
Fractional Ca2+ excretion, % | 0.49 ± 0.05 | 0.86 ± 0.28 |
Na+/K+ ratio | 0.57 ± 0.12 | 0.78 ± 0.06 |
