Table 2 Description of pathways overrepresented in co-expression modules associated to feed efficiency identified in both liver and duodenum tissues.

From: Integrative approach using liver and duodenum RNA-Seq data identifies candidate genes and pathways associated with feed efficiency in pigs

Cannonical Pathways

Tissues (Module)

-log(p-value)

Genes

Aldosterone Signaling in Epithelial Cells

duodenum (Darkgreen)

5.80

HSPH1,DNAJB1,DNAJA1,HSPA2,HSPA4L

liver (Yellow)

4.79

HSPA4,CRYAB,HSP90AB1,DNAJB4,SGK1,HSPH1,HSPB8,HSPD1,DNAJA1,HSPA2,DNAJB5,HSPA4L

Cell Cycle: G1/S Checkpoint Regulation

duodenum (Salmon)

1.64

RPL11,RPL5

liver (Yellow)

1.71

MYC,SMAD3,CDKN2C,E2F3

IL-1 Signaling

duodenum (Salmon)

1.35

TRAF6,GNAS

liver (Yellow)

2.46

FOS,JUN,NFKBIE,NFKB2,NFKB1,IRAK2

IL-8 Signaling

duodenum (Salmon)

1.44

TRAF6,GNAS,PGF

liver (Yellow)

4.72

FOS,VCAM1,JUN,ICAM1,RND3,RHOB,HBEGF,VEGFC,LIMK2,PTGS2,NFKB1,FNBP1,IRAK2

NRF2-mediated Oxidative Stress Response

duodenum (Darkgreen)

2.78

NQO1,DNAJB1,DNAJA1

liver (Yellow)

4.15

FOS,UBB,JUN,DNAJB4,GSTA4,STIP1,DNAJA4,HSPB8,DNAJA2,DNAJA1,MAFF,DNAJB5

Role of RIG1-like Receptors in Antiviral Innate Immunity

duodenum (Darkred)

1.32

CASP10

liver (Yellow)

1.50

NFKBIE,NFKB2,NFKB1

Unfolded protein response

duodenum (Darkgreen)

2.7

HSPH1,HSPA2

liver (Yellow)

3.66

HSPA4,INSIG1,HSPH1,PPP1R15A,DNAJA2,HSPA2

Protein Ubiquitination Pathway

duodenum (Darkred)

1.48

HSPE1,ANAPC10

duodenum (Darkgreen)

4.89

HSPH1,DNAJB1,DNAJA1,HSPA2,HSPA4L

liver (Yellow)

5.40

UBB,CRYAB,DNAJB4,HSPH1,HSPB8,THOP1,HSPD1,DNAJA1,HSPA2,HSPA4,HSP90AB1,UBE2B,NEDD4L,DNAJB5,HSPA4L,BIRC2