Table 6 Interaction of active site residues in wild-type and alanine mutated complexes.
Interactions | Wild-type | H44A | H47A | N69A | Q72A | K160A | Q164A |
|---|---|---|---|---|---|---|---|
44–47 | H. bond, VDW | H. bond, VDW | H. bond, VDW | H. bond, VDW | H. bond, VDW | H. bond, VDW | H. bond, VDW |
44–48 | H. bond | H. bond, VDW | H. bond, | H. bond, VDW | H. bond, VDW | H. bond, | H. bond, |
44–195 | VDW | — | VDW | — | VDW | VDW | VDW |
44–196 | — | — | — | — | VDW | — | VDW |
44–197 | H. bond | — | VDW | — | VDW | — | — |
47–50 | H. bond | H. bond | — | H. bond | H. bond | H. bond | H. bond |
47–197 | — | — | — | — | VDW | — | — |
69–139 | — | — | — | — | — | — | VDW |
72–114 | — | — | — | — | — | — | VDW |
72–117 | — | — | VDW | — | — | — | — |
72–134 | — | — | — | — | VDW | VDW | — |
72–135 | VDW | VDW | — | — | VDW | — | H. bond |
72–139 | VDW | — | — | — | — | — | VDW |
160–186 | — | — | VDW | VDW | — | — | — |
160–196 | H. bond | H. bond | — | H. bond | H. bond | — | H. bond |
160–194 | — | — | — | — | — | — | VDW |
160–195 | H. bond | H. bond | — | H. bond | H. bond | — | H. bond |
160–198 | — | — | — | VDW | — | — | — |
160–282 | — | — | — | — | H. bond | — | H. bond |
164–157 | VDW | — | — | — | — | — | — |
164–167 | — | VDW | H. bond | — | H. bond | H. bond | — |
164–168 | H. bond | H. bond, VDW | H. bond, VDW | H. bond | H. bond, VDW | H. bond | — |
