Figure 3

Box plots showing simulated blood velocity and flow changes in response to vasoconstriction. The top row of graphs shows blood velocity changes as a percentage of the baseline solution, and the bottom row shows blood flow changes. From left to right, plots show the responses to constrictions in penetrating arterioles (left), precapillary arterioles (middle) and capillaries (right). Results are presented for each constriction scenario (1) single-cell constriction, (2) constriction of the entire vessel, (3) bi-directional and (4) uni-directional constriction of the local penetrating arteriole. Note, cases (2) and (3) are equivalent for penetrating arterioles and the mean values for each are indicated with circles. Case 4 for penetrating arterioles provides the velocity change for the neighbouring downstream vessel from the site of constriction. Mean values are indicated in blue. See Supplementary Fig. S2 for outliers.