Figure 4

Simulated single vessel constrictions and the subsequent change in vessel and tissue PO₂. Box plots indicated the percentage change in vessel PO₂ in constricted (a) penetrating arterioles, (b) precapillary arterioles and (c) capillaries, when compared to baseline PO₂ in said vessel. Noting, for (a,b) constriction cascade is induce by constriction of SMA-covered vessels. (d) The percentage change in local tissue PO₂ as a consequence of constrictions in (c). Mean values are indicated in blue and outliers (data larger than q₃ + 3(q₃ − q₁)/2 or smaller than q₁ − 3(q₃ − q₁)/2, where q₁ and q₃ are the 25^th and 75^th percentiles, respectively) by red crosses.