Table 4 Univariate and multivariable analysis of factors associated with overall survival in bladder cancer patients who underwent radical cystectomy including HALPA.

From: Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Gender (female vs. male)

0.794(0.528–1.193)

0.264

  

Age (>65 vs. ≤65)

2.220(1.592–3.098)

0.001

1.849 (1.294–2.641)

0.001

Smoking history

1.014(0.725–1.417)

0.937

  

Alcohol-drinking history

0.922(0.565–1.504)

0.743

  

Hypertension

1.130(0.803–1.591)

0.480

  

Histology type (TCC vs. no-TCC)

0.706(0.331)1.506

0.363

  

G (3 vs. 2)

2.118(1.373–3.267)

<0.001

  

T (MIBC vs. NMIBC)

4.301(2.665–6.942)

<0.001

2.831 (1.720–4.658)

<0.001

N (positive vs. negative)

2.448(1.716–3.491)

<0.001

2.135 (1.448–3.146)

<0.001

M (positive vs. negative)

10.509(3.842–28.746)

<0.001

3.807 (1.278–11.336)

0.016

Adjunctive chemotherapy

2.056(1.437–2.941)

<0.001

  

ASA (3&4 vs. 1&2)

2.068(1.442–2.964)

<0.001

  

Hypoalbuminemia

2.919(1.900–4.484)

<0.001

  

Anemia

2.433(1.775–3.335)

<0.001

  

PLR

1.963(1.421–2.712)

<0.001

  

HALP

2.820(1.976–4.025)

<0.001

  

HALPA

 

<0.001

 

<0.001

   0

1

 

1

 

   1

2.084(1.477–2.941)

<0.001

1.624 (1.139–2.314)

0.007

   2

6.300(3.628–10.940)

<0.001

3.471 (1.861–6.472)

<0.001

  1. TCC, transitional cell carcinoma; MIBC, muscle-invasive bladder cancer; NMIBC, non-muscle invasive bladder cancer; ASA, American Society of Anesthesiologists; PLR: platelet to lymphocyte ratio; HR, hazard ratio; CI: confidence interval.
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