Table 3 Overview of the main associations of clinical parameters with N-glycans.

From: Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients

Glycan trait

Peritonitis

DPCrea4

IL-6

IL-8

MCP-1

HA

TGFβ-1

VEGF

CA-125

Sample_Trait

Description

OR (95% CI)

Regression coefficient B (95% CI)

Se_A2

Relative abundance of diantennary species (A2)

a)

a)

−0.065 1

(−0.108; −0.022)

−0.061 1

(−0.114; −0.008)

a)

a)

−0.037°

(−0.071; −0.002)

−0.089°

(−0.141; −0.037)

a)

Ef_A2

a)

−0.008°

(−0.016; −0.001)

a)

−0.101 3

(−0.190; −0.013)

a)

a)

−0.055°

(−0.091; −0.020)

a)

a)

Se_A3

Relative abundance of triantennary species (A3)

a)

a)

0.077°

(0.028; 0.125)

0.073°

(0.011; 0.136)

a)

a)

0.039°

(0.003; 0.076)

0.093°

(0.038; 0.148)

a)

Ef_A3

a)

0.013 2

(0.004; 0.022)

0.121 2

(0.032; 0.210)

0.140 3

(0.029; 0.252)

a)

a)

0.083°

(0.037; 0.129)

0.123 2

(0.028; 0.217)

a)

Ef_A2F

Relative fucosylation of A2

1.047 3

(1.000; 1.097)

a)

a)

a)

a)

a)

a)

a)

−0.022°

(−0.042; −0.002)

Se_A3F

Relative fucosylation of A3

a)

a)

a)

0.016 1

(0.000; 0.032)

a)

a)

a)

a)

a)

Ef_A3F

a)

a)

0.026 0

(0.012; 0.040)

a)

a)

a)

a)

a)

a)

Se_A2B

Relative bisection of A2

a)

a)

a)

0.068 3

(0.001; 0.135)

a)

a)

a)

a)

a)

Ef_A2B

a)

a)

a)

0.076 3

(0.002; 0.151)

a)

a)

a)

a)

 

Se_A2G

Relative galactosylation of A2

a)

a)

a)

a)

a)

a)

−0.028 2

(−0.053; −0.004)

a)

a)

Ef_A2G

0.871 3

(0.784; 0.967)

a)

a)

a)

a)

a)

a)

a)

0.045 2

(0.016; 0.074)

Ef_A2L

Relative α2,3-N-sialylation per antenna within A2

a)

−0.034 1

(−0.064; −0.004)

−0.403 3

(−0.723; −0.082)

a)

a)

a)

a)

a)

a)

Ef_A3L

Relative α2,3-N-sialylation per antenna within A3

a)

a)

a)

0.080 3

(0.015; 0.144)

a)

a)

a)

a)

a)

Ef_A2E

Relative α2,6-N-sialylation per antenna within A2

0.934 3

(0.876; 0.996)

a)

a)

a)

a)

a)

a)

a)

0.033 0

(0.009; 0.056)

Se_A3E

Relative α2,6-N-sialylation per antenna within A3

a)

a)

0.088 0

(0.020; 0.157)

a)

a)

a)

a)

a)

a)

Ef_A3E

1.205 0

(1.004; 1.446)

0.005 1

(0.001; 0.010)

0.113 0

(0.057; 0.169)

0.062 1

(0.008; 0.117)

0.041 0

(0.012; 0.070)

0.049 0

(0.023; 0.076)

0.052 3

(0.026; 0.079)

0.082 0

(0.044; 0.121)

a)

Ef_IgG

Relative abundance of primarily IgG-derived glycans

1.116 3

(1.017; 1.225)

a)

a)

a)

a)

a)

a)

a)

−0.045 0

(−0.072; −0.018)

Ef_H3N4F1

Relative abundance of H3N4F1

1.297 3

(1.098; 1.532)

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Ef_H3N5F1

Relative abundance of H3N5F1

2.156 1

(1.192; 3.898)

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  1. Displayed are odds ratios (OR) derived from logistic regression and regression coefficients B from linear regression along with their 95% confidence intervals, both using GEE for a robust estimation of the standard errors. Only associations with p < 0.05 and a 10%-cutoff for the change in estimate by confounders are shown, while associations not matching these criteria are listed in Supporting Information Table S-3 (here marked with a)). Thus, high-mannose trait (M) in either serum or effluent, in addition to A2F, A2L, A3L, A2E and IgG in serum are not listed. Associations for direct traits with the compositions H3N4F1 and H3N5F1 were only tested for effluent, but not serum. Se, glycans from serum; Ef, glycans from PD effluent; H, hexose; N, N-acetylhexosamine; F, fucose.
  2. The following models were used: 0, crude analysis; 1, model 1 with adjustment for age, sex, diabetes; 2, model 2 with adjustment for CAPD/APD, time on PD and Dianeal/Physioneal group; 3, model 1 + 2. Relative signal intensities of the derived glycan traits were calculated as %-values, and levels of IL-6, IL-8, MCP-1, HA, TGFβ-1, VEGF and CA-125 were ln-transformed prior to regression analysis. Negative and positive associations are formatted in italic and bold, respectively; not tested associations are depicted as [---]. For calculations of derived trait abundances, see Supporting Information Table S-1 and S-2.