Figure 3 | Scientific Reports

Figure 3

From: Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages

Figure 3

Dot plot representation of the effect of dementia on the expression of glutamatergic markers. VGLUT1, VGLUT2, EAAT2 and PSD95 were measured by western blot coupled to infrared detection and the expression levels (in arbitrary units) were plotted against the CDR scores. Values for each individual are represented by dots. The mean is depicted as the black line in the middle of a box representing the SEM. VGLUT1 expression was significantly reduced at CDR scores of 3 and 5 (p < 0.05), whereas VGLUT2 and EAAT2 expression were not modified regardless of the cognitive status of the patient. PSD95 showed a decrease during the last stage only at CDR scores of 5. *p < 0.05.

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