Figure 7 | Scientific Reports

Figure 7

From: Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages

Figure 7

Dot plot representation of the effect of dementia on ChAT, synaptophysin and α-tubulin expression. ChAT activity (A) was measured in the BA9 extracts, whereas synaptophysin (B) and α-tubulin (C) were detected by western blot. Corresponding values were plotted against the CDR scores. Dots represent individual values. The mean is represented by the black line, and the SEM is represented by the coloured box. ChAT and synaptophysin expression were significantly reduced in individuals with CDR scores of 5 (p < 0.05), whereas α-tubulin expression was only modified at CDR scores of 3. *p < 0.05.

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