Figure 8 | Scientific Reports

Figure 8

From: Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages

Figure 8

Polyserial and Pearson correlation analyses. Polyserial (ρ) and Pearson (r) correlation coefficients between the CDR scores and VGLUT1, VGLUT2, somatostatin (Som), ChAT, VIAAT, EAAT2, α-tubulin, synaptophysin (syn) and PSD95 were determined. The various correlation coefficients were colour coded from dark blue for a correlation of 1 to a deep red for −1 (and white for 0). Polyserial correlations between the markers and CDR scores are represented by the dashed boxes on the first row. Pearson correlations are presented between the different markers. VGLUT1 shows a negative correlation with the CDR scores, which was higher than that of somatostatin, VIAAT and synaptophysin (r < −0.3). The Pearson correlations highlighted a positive correlation between VGLUT1 vs. α-tubulin, PSD95 and VIAAT (r > 0.46) and between PSD95 vs. VIAAT and synaptophysin (r > 0.5). The p-values of the Pearson correlation analyses are presented in Table 2.

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