Table 1 Crystallographic statistics of the CRBN TBD bound to thalidomides.

From: Structural basis of thalidomide enantiomer binding to cereblon

 

(S)-thalidomide

(R)-thalidomide

(RS)-thalidomide (racemic)

Space group

R3 (H)

R3 (H)

R3 (H)

Unit cell a = b = (Å)

201.90

202.24

201.38

   c = (Å)

123.61

123.82

123.36

   γ = (°)

120

120

120

Wavelength (Ã…)

1.28268

0.9000

1.0000

Resolution rangea (Ã…)

50–1.8

50–2.0

50–2.0

  (Outer shell)

(1.86–1.8)

(2.05–2.0)

(2.07–2.0)

Completeness (%)

100 (100)

99.9 (99.9)

100 (100)

Reflectionsb

Oscillation range (°)

180

180

180

Measured

974,617

752,877

723,800

Unique

173,436

130,317

125,695

Multiplicity

5.6

5.8

5.8

Mosaicity (°)

0.38

0.41

0.33

I/σ(I)

17.8 (3.1)

20.6 (3.9)

20.6 (4.6)

Rmerge(%)

8.1 (50.0)

7.8 (49.3)

7.8 (41.0)

  1. aValues in parentheses are for the highest-resolution shell.
  2. bData were collected at SPring-8 beamline BL44XU with a MX225HE detector (each 1° oscillation with 1 s exposure time for the (S)-thalidomide-bound form, 0.5° oscillation with 1.2 s exposure time for the (R)-thalidomide-bound form and each 1° oscillation with 1 s exposure time for the (RS)-thalidomide-bound form) at 100 K.
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