Figure 1

Prior exhaustive exercise prevents olanzapine-induced increases in blood glucose. Mice ran on a motorized treadmill to exhaustion (a,b) or 75 minutes of moderate (15 m/min) exercise (c,d) prior to treatment with olanzapine (5 mg/kg bw) or vehicle. Blood glucose was measured prior to and 30, 60 and 90 minutes following treatment (a,c) and the glucose area under the curve (AUC) calculated (b,d). Data are presented as means ± SEM for 6–12 mice/group. Groups were compared by 2-way ANOVA. There was a significant interaction (p = 0.007) between exhaustive exercise and olanzapine such that olanzapine increased the blood glucose AUC in sedentary mice (*) while the glucose AUC was different ($) between sedentary and exercised mice treated with olanzapine. *Main effect of olanzapine for increasing blood glucose in the moderate exercise experiment.