Figure 5

The protective effects of exercise against olanzapine-induced hyperglycemia are intact in IL-6^−/− mice. WT or IL-6^−/− mice underwent the exhaustive exercise protocol and then immediately were treated with olanzapine (5 mg/kg bw) or vehicle. Blood glucose was measured prior to and 30, 60 and 90 minutes post treatment (a,b) and the glucose area under the curve (AUC) calculated (c). Serum insulin concentrations were determined 90 minutes following olanzapine treatment in exercised WT and IL-6^−/− mice (d). Data are presented as means ± SEM for 6–10 mice/group. Groups were compared by a 3 (c) or 2 (d) way ANOVA. ^$Significant interaction (p < 0.001) in (c) such that sed-OLZ was different than sed-V and ex-OLZ. ^$Significant interaction (p = 0.003) such that WT olanzapine is different that WT vehicle in d. sed-V = sedentary vehicle, sed-olz = sedentary olanzapine, ex–V = exercise vehicle, ex-OLZ = exercise olanzapine.