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Figure 1

From: Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy

Figure 1

Pre-gestational diabetes significantly impairs preimplantation embryo viability. Control (black) and diabetic (grey) female mice were hormone-stimulated and mated, then embryos were flushed from the oviduct on d1.5 p.c (A–C) and uterus on d3.5 p.c (D–F). Conception rate (proportion of females with at least one viable embryo following mating, A), total 2-cell embryo number (B), % viable 2-cells (C), total embryos on d3.5 p.c. (D), viable embryos on d3.5p.c. (E) and blastocyst rate (F) were assessed (n = 13 females mated per treatment, per time point). Data is presented as mean + SEM and effects of treatment were analysed by unpaired Student’s t-test. *P < 0.05.

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