Figure 6 | Scientific Reports

Figure 6

From: Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells

Figure 6

PrognoScan analysis of TRAF4 in oesophageal cancer. (A) Oesophageal cancer data posted in PrognoScan. (B) TRAF4 expression plot. Red plots indicate patients with highly expressed TRAF4. Blue plots indicate patients with low TRAF4 expression. (C) Kaplan–Meier plot. Red line indicates patients with high TRAF4 expression. Blue line indicates patients with low TRAF4 expression. (D) Quantitative RT-PCR of TRAF4 expression level in the parental TE4 and TRAF4-overexpressing OE-TE4 cells. The data were normalised by GAPDH expression level. (E) Representative tumour tissues excised from mice 20 days after tumour volumes reached 100 mm3, and 5-FU (20 mg/kg) was administered every 2 days. (F) Relative tumour volumes are shown 20 days after tumour volumes reached 100 mm3, and 5-FU was administered, corresponding to (E).

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