Figure 8 | Scientific Reports

Figure 8

From: AV2 protein of tomato leaf curl Palampur virus promotes systemic necrosis in Nicotiana benthamiana and interacts with host Catalase2

Figure 8

A schematic hypothesis for the role of the AV2 protein during ToLCPalV infection. ROS are generated as a result of virus entry into the cell. Expression of PAD4 might prime salicylic acid (SA) via the PAL pathway. SA priming might lead to expression of NPR1, which eventually induces expression of stress markers (PR1 & PR5). The downregulation of EDS1 might have weakened the SA accumulation and renders the host susceptible for the virus infection. Further, AV2 (dimer) interaction with Cat2 might downregulated its expression and activity to prevent ROS dismutation, ultimately resulting in systemic necrosis. AV2 also suppress siRNA signals against PDS targeted by the host RNA silencing machinery. Green and red lines represent up- and downregulated transcripts, respectively.

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