Figure 1

Relationships between EMPs and the KD patients with or without CAL. (a) EMPs are significantly upregulated in patients with KD among the enrolled patients. The percentage of EMPs in patients with KD before the initial treatment are compared to the controls. In patients with KD (n = 50), the percentage of EMPs was 1.31 ± 0.16% in KD patients before treatment, which was significantly higher level compared to either healthy children (0.09 ± 0.03%) (n = 25) or children with febrile disease (0.08 ± 0.03%) (n = 25). Boxes and whiskers represent either quartiles or end-points respectively. All values represent the mean ± SD. ****P < 0.0001. (b) EMPs are specifically increased in patients with CAL of KD at Stage-2. In patients with NCAL of KD (blue solid circles), EMPs are decreased after defervescence during Stage-1 to Stage-3. In contrast to this, EMPs in patients with CAL of KD (red solid circles) are significantly increased at Stage-2 compared to patients with NCAL of KD, whereas EMPs are comparable between patients with CAL and NCAL of KD either Stage-1 or Stage-3. n = 45 patients with NCAL of KD (blue solid circles), n = 5 patients with CAL of KD (red solid circles). All values represent the mean ± SD. ***P < 0.001. ns, not significant. (c) Correlation between EMPs and the maximum Z-score of right or left coronary artery diameters. Significant correlation can be observed between the percentage of EMPs and the maximum Z-score of right or left coronary artery diameters. Blue solid circles show patients with NCAL of KD, and red solid circles indicate patients with CAL of KD.