Figure 6 | Scientific Reports

Figure 6

From: MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease

Figure 6

The target mRNAs are downregulated in THP-1 monocytes after transfection of the selected miRs. The BMPR1A and TMEM9B mRNAs after transfection of hsa-miR-320a, hsa-miR-145-5p and a negative control to THP-1 monocytes in the presence or absence of LPS. This experiment was repeated 3 times. BMPR1A is significantly suppressed by transfection of hsa-miR-320a and treated with LPS compared to that of controls (a, 30.2% downregulation vs. negative control), whereas transfection of hsa-miR-145-5p shows similar induction level of BMPR1A compared to controls (ns, not significant). TMEM9B is significantly suppressed by transfection of hsa-miR-145-5p, but not hsa-miR-320a (ns), and treated with LPS compared to that of controls (b, 35.0% downregulation vs. negative control). All values represent the mean ± SD. *P < 0.05.

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