Figure 1
From: Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis
Treatment schedule and CT measurement of rat lungs after thoracic irradiation. (A) Rats were irradiated with a dose of 20 Gy to the right thorax at time point zero to initiate pulmonary fibrosis and were treated with JQ1 or vehicle for 9 days 24 h before the irradiation. Sham-treated rats were served as controls. Rats were monitored by histology and by noninvasive radiological methods allowing for longitudinal analysis. (B) CT was used for evaluation of fibrosis. Representative CT imaging showed progression of lung fibrosis in rats after 20 Gy right hemithoracic radiation with or without JQ1. (C) Quantitative lung density values were defined in Hounsfield Units (HU) (n = 3). Mean ± SE are presented. (D) Changes of animal body weight after radiation and JQ1treatment (n = 3). Mean ± SD are presented. *P < 0.05 vs. Radiation group, **P < 0.01 vs. Radiation group.
