Table 1 Clinical data between Alzheimer’s disease (AD) patients and age-matched controls.
AD (n = 50) | Control (n = 30) | |
|---|---|---|
Age (years) | 73.32(8.40) | 71.03(8.05) |
Education (years) | 5.3(4.51)* | 8.5(5.22) |
Gender (female, %) | 33(66%) | 18(60%) |
Diabetes Mellitus, cases (%) | 9(18%) | 6 (20%) |
Hypertension, cases (%) | 29(58%) | 17(56.7%) |
APOE4 carrier, cases (%) | 27(54%)* | 6(20%) |
High sensitivity C- reactive protein (mg/L) | 2.94(3.53) | 1.72(1.61) |
Creatinine (mg%) | 0.90(0.26) | 0.91(0.25) |
Total cholesterol (mg/dl) | 195(37.8) | 180(29.0) |
Triglyceride (mg/dl) | 116(59.4) | 109(47.2) |
High-density lipoprotein (mg/dl) | 57.3(13.3) | 55.7(16.7) |
Low-density lipoprotein (mg/dl) | 112(30.2) | 104(29.3) |
Mini-Mental State Examination | 16.78(5.13)* | 27.07(1.91) |
CASI total scores | 56.46(17.61)* | 85.81(6.00) |
Mental manipulation | 4.4(3.16)* | 8.4(1.59) |
Attention | 5.8(1.41)* | 6.9(0.92) |
Orientation | 10.6(4.56)* | 17.1(2.26) |
Long term memory | 7.4(2.75)* | 9.6(0.81) |
Short term memory | 3.0(2.08)* | 8.9(1.51) |
Abstract thinking | 6.8(2.40)* | 9.1(1.63) |
Drawing | 6.3(3.42)* | 9.3(1.06) |
Language Composite scores | 11.5(4.73)* | 16.5(2.43) |
Cerebral blood flow(ml/100 g/min) | ||
Global | 40.4(9.76)* | 47.1(7.13) |
Frontal cortex | 44.6(10.4)* | 50.6(7.01) |
Lateral temporal regions of interest | 42.5(7.54)* | 49.0(6.97) |
Medial temporal cortex | 40.0(9.23)* | 43.8(5.29) |
Occipital cortex | 34.0(10.1)* | 43.2(9.23) |
Parietal cortex | 37.9(10.7)* | 46.2(8.61) |
