Figure 2
CT imaging example of the location pattern of sclerotic bone lesions in the skull, spine, and pelvis of TSC patients and control subjects. (A1,A2) Transversal CT of the skull of a TSC patient and a control subject. (A1) A relatively high number of SBLs (indicated by white arrows) can be seen in the spongiosa of the skull. The highest number of SBLs can be found in the os parietale and the os frontale. (A2) Normal spongiosa of a control individual without focal sclerotic bone lesions. (B1,B2) Transversal CT of the spine in a TSC patient and a control subject. (B1) The highest number of SBLs (indicated by white arrows) can be detected in the thoracic spine in the vertebral body and the arcus vertebrae/processus spinosus. Other osseous structures (e.g. sternum or ribs) were also affected, but to a lesser degree. (B2) Normal spongiosa of a control individual without focal sclerotic bone lesions. (C1,C2) Transversal CT of the pelvis in a TSC patient and a control subject. (C1) In the abdomen/pelvis, the second-highest number of SBLs (indicated by white arrows) could be detected in the pelvis. The highest number could be detected in the spine (example please see Fig. 2, B1). Other osseous structures such as the femur were also affected, but to a lesser degree. (C2) Normal spongiosa of a control individual without focal sclerotic bone lesions.
