Figure 3
Frequency and location pattern of sclerotic bone lesions in TSC patients and control subjects. The average number of SBLs per patient and the average size of SBLs is given for the different regions investigated by CT. (A) In the CT scan of the skull, the highest number of SBLs per TSC patient was found in the os parietale and os frontale, while only a small number of SBLs was found in the control collective (A1) The size of SBLs did not differ significantly between the different regions (A2). (B) The overall highest number of SBLs per TSC patient was found in the CT of the thorax (B1). The frequency of SBLs was highest in the thoracic spine. Besides the thoracic spine, SBLs also occurred relatively frequently in the sternum and ribs (B1). The average size of SBLs of TSC patients in the spine was significantly higher compared to the control collective (B2). (C) A relatively high number of SBLs per TSC patients was found in the abdomen/pelvis (C1). The highest frequency of SBLs was observed in the spine, followed by the pelvis and the femur. The frequency of SBLs in the control collective was relatively low. Size measurements differed significantly between TSC patients and the control (C2). *Indicates a significant difference (p < 0.05) between TSC patients and the matched control collective.
