Table 2 Summary of cutoff values for SBLs frequencies in the different investigated regions.

From: Sclerotic bone lesions as a potential imaging biomarker for the diagnosis of tuberous sclerosis complex

Body region

Cut-off for SBL frequency

Sensitivity

Specificity

PPV

NPV

Youden-Index

Skull

≥5

78.3%

100%

100%

82.1%

0.78

Thorax

≥4

96.7%

96.7%

96.7%

96.7%

0.93

Abdomen/Pelvis

≥5

93.8%

90.6%

90.9%

9.6%

0.84

Skull + Thorax

≥5 + ≥ 4

99.3%

100%

100%

99.4%

0.99

Skull + Abdomen/Pelvis

≥5 + ≥ 5

98.6%

100%

100%

98.9%

0.99

Thorax + Abdomen/Pelvis

≥4 + ≥ 5

99.8%

99.7%

99.7%

99.8%

0.99

  1. PPV: Positive predictive value, NPV: Negative predictive value, SBL: Sclerotic bone lesion.