Figure 5
Effect of cathelicidin-OA1 on the repair rate of HaCaT cell wounds (scratches). (A) Cathelicidin-OA1 (10 μM) illustrated obvious HaCaT cell wound-healing activity. (B) Cathelicidin-OA1 (10 μM) illustrated no obvious HaCaT cell wound-healing activity when proliferation was inhibited by mitomycin C. (C) Cathelicidin-OA1 illustrated time- and dose-dependent HaCaT cell wound-healing activity. (D) Cathelicidin-OA1 illustrated no time- or dose-dependent HaCaT cell wound-healing activity when proliferation was inhibited by mitomycin C. (E) At concentrations of 10 nM to 10 μM, cathelicidin-OA1 showed proliferative effects on HaCaT cells. ‘Vehicle’ is the negative control; *P < 0.05 and **P < 0.01 indicated significantly different from the vehicle (Student’s t-test). Data are mean values of three independent experiments performed in triplicate.
