Figure 1
The RdRp domain is conserved between HCV and ZIKV. (a) Phylogenetic dendrogram showing HCV and ZIKV belonging to Hepacivirus and Flavivirus genera, respectively, within the Flaviviridae family. Phylogenetic tree of RNA polymerase domain of HCV and ZIKV strains was based on Maximum-likelihood approach. This tree is intended to highlight the degree of similarity (branch length) of the RNA polymerase from different viruses. The longer the branch is in the horizontal dimension, the larger the amount of change. The units of branch length are amino acid substitutions per site. (b) Schematic of HCV and ZIKV protein structures. Both viruses have their RNA-dependent polymerases (RdRp) within the NS5B and NS5 domains, respectively. (c) Capsid protein; prM: precursor of Membrane protein; E: Envelope protein; p7: Viroporin, NS: Non-structural proteins. (c) RNA polymerase amino acid sequence conservation and DPP domain between different members of Flaviviradae family including HCV, West Nile virus, Japanese encephalitis, Dengue virus and ZIKV. Highlighted sequences correspond to amino acid sequence conservation between strains. Light gray corresponds to amino acid conservation in 4 strains, and dark gray correspond to amino acid conservation in 5 strains (all represented strains). The blue box indicated by the arrow corresponds to the GDD amino acid domain that is conserved in all 5 represented virus strains (highlighted as dark gray).
