Figure 3 | Scientific Reports

Figure 3

From: Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH

Figure 3

CANA reduces inflammation and fibrosis in adipose tissue of WD-fed MC4R-KO mice. (a) F4/80 immunohistochemical analysis of epididymal fat. (b) Adipocyte area in epididymal fat. (c) Quantification of the number of crown-like structure (CLS) in epididymal fat. (d) Expression levels of inflammation-related genes in epididymal fat. (e) Sirius red staining of epididymal fat and (f) quantification. (g) Expression levels of collagen genes in epididymal fat. Original magnification, ×200. Scale bars, 100 μm. *p < 0.05, **p < 0.01 vs MC4R-KO/WD. Statistical analyses were performed using Kruskal‐Wallis test (b and f) or one-way ANOVA (c,d and g) followed by Dunn or Bonferroni post hoc test, respectively; MC4R-KO/WD and MC4R-KO/WD/CANA was pre-selected as a subset of means or medians to compare. n = 15.

Back to article page