Table 3 Hazard ratios and 95% confidence intervals for mortality according to quartiles of liver enzymes after myocardial infarction or ischemic stroke.

From: Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study

  

Event

Duration

MR

Model 1

Model 2

HR (95% Cl)

HR (95% Cl)

ALT

Q1

6218

21507006

0.29

1.00 (Ref)

1.00 (Ref)

Q2

3841

20805510

0.18

0.73 (0.70, 0.76)

0.80 (0.76, 0.83)

Q3

3571

22471487

0.16

0.70 (0.67, 0.73)

0.80 (0.77, 0.84)

Q4

3252

21550048

0.15

0.78 (0.74, 0.81)

0.93 (0.89, 0.97)

AST

Q1

5024

23428822

0.21

1.00 (Ref)

1.00 (Ref)

Q2

3378

18599784

0.18

0.83 (0.80, 0.87)

0.87 (0.83, 0.91)

Q3

3929

22604257

0.17

0.80 (0.77, 0.83)

0.85 (0.82, 0.89)

Q4

4551

21702283

0.21

1.02 (0.98, 1.06)

1.09 (1.04, 1.13)

GGT

Q1

4622

20642384

0.22

1.00 (Ref)

1.00 (Ref)

Q2

4061

21699165

0.19

0.93 (0.89, 0.97)

1.03 (0.99, 1.07)

Q3

3740

22372024

0.17

0.92 (0.88, 0.96)

1.08 (1.04, 1.13)

Q4

4459

21619018

0.21

1.24 (1.19, 1.29)

1.46 (1.40, 1.52)

  1. MR, mortality rate (per 1000 person-years); HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase.
  2. Model 1: HRs were analyzed after adjusting for age and sex.
  3. Model 2: HRs were analyzed after adjusting for age, sex, body mass index, smoking, alcohol, exercise, diabetes, hypertension, and dyslipidemia.