Figure 5 | Scientific Reports

Figure 5

From: LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor

Figure 5

Effect of Amino acid substitutions within α4 extracellular and transmembrane domains on LY2087101 and dFBr potentiation of (α4)3(β2)2 nAChR. Representative two-electrode voltage clamp traces showing the effect of 1 μM LY2087101 or 1 μM dFBr on ACh-induced current responses of Xenopus oocytes expressing (α4)3(β2)2 nAChRs containing an amino acid substitution at the α4 subunit extracellular domain (A) or within the α4 subunit transmembrane domain (B and C).

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